Mexedrone is an illegal synthetic stimulant drug that belongs to the cathinone class. It has been sold online as a “designer drug” or as “research chemicals,” often appearing in crystalline powder or tablet form. It is also known as 4-MMC-MeO, and it is the alpha-methoxy derivative of the more well-known drug, mephedrone.
Risks and effects
Mexedrone is illegal and its use carries serious and unpredictable health risks, including potential overdose and death. Because it is an unregulated substance, its purity and dosage are inconsistent, further increasing its danger.
Effects and risks include:
- Stimulant and entactogenic effects: Similar to mephedrone, mexedrone can cause euphoria, increased energy, enhanced sociability, and an elevated mood.
- Cardiovascular issues: It can cause a rapid heart rate, high blood pressure, and chest pains.
- Neurological and psychological effects: Users have reported agitation, aggression, anxiety, paranoia, and even hallucinations and delusions.
- Other physical symptoms: Nausea, vomiting, sweating, and teeth grinding can also occur.
- Toxicity and overdose: An overdose can lead to acute kidney injury, seizures, psychosis, and in extreme cases, stroke, heart attack, or death.
Mechanism of action
Similar to other synthetic cathinones, mexedrone acts on the brain’s monoamine transporters for dopamine, norepinephrine, and serotonin. However, it is considered a weak inhibitor of the reuptake of these neurotransmitters and a weak serotonin-releasing agent. This could lead users to take larger doses to achieve the desired effect, which increases the risk of serious health consequences